Abnormal liver function can also use finasteride it?

With androgenetic alopecia getting larger and larger crowds, some big, three positive hepatitis B and hair Human Hair Wigs loss medication in patients also appear more and more questions, abnormal liver function, can have use of finasteride it?

First of all, tell us about the metabolism of the drug. After gastrointestinal absorption of oral drugs, are to be converted in the liver to make it to inactive or solubility of the material, with the bile or urine excreted. The drug is one of the important cause of liver injury, drug-induced liver disease mechanism varies due to the drug is very complicated and in most cases is not clear. Some drugs have a direct toxic effect caused by liver damage can be expected in general, damage and dose-related; others in sensitive individuals drugs occasionally cause liver damage, regardless of the dose, the occurrence or not is difficult to predict.

Experiments proved that finasteride is not directly toxic to the liver, finasteride major metabolites catalyzed cytochrome P450 enzymes. 1 man taking finasteride after 14C-labeled, two kinds of non-detectable metabolites that finasteride, which inhibit 5α-reductase activity is much lower than finasteride. This shows that finasteride easily metabolized by the liver, the drug is not toxic after conversion.

1 man taking finasteride 14C-labeled after 39% of the drug in the form of metabolites excreted in urine (in fact, no unchanged drug excreted in urine), 57% of the drug excreted with the feces. This shows that 96% of the drug will eventually be excreted, finasteride dose is small, does not accumulate. If hair loss in patients with chronic hepatitis, the best medication during regular check liver function.